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Running exercise may boost sensitivity to leptin, a hormone released from excess fat cells that inhibits diet. The authors’ new research reveals extra mechanisms that contribute the helpful effects of exercise. Related StoriesAfrican-Us citizens who did not take part in exercise nearly doubly likely to misuse alcoholLow-weight, high-repetition weight training increases bone relative density in adultsExercise can guard brain function, decrease occurrence of PTSDGut hormones are released before and after meals to initiate and terminate diet.Markowitz likens the 15-PGDH gene to a naturally occurring COX-2 inhibitor. Markowitz found that 15-PGDH is directly managed and activated by another gene, called TGF-beta. Normally, TGF-beta sends a sign that allows the colon to shed cells every week as a means of helping to block advancement of colon cancers. In 1995, Markowitz discovered colon cancers possess mutations that inactivate the TGF-beta pathway. ‘When there is no TGF-beta signal, there is absolutely no 15-PGDH. That means the opponent to COX-2 is gone, and the COX-2 oncogene activity is normally unopposed,’ stated Markowitz. ‘This interaction between TGF-beta and 15-PGDH factors to the need for the TGF-beta system in suppressing cancer of the colon.