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In the face of excessive IDO, too much of the essential amino acid L-tryptophan gets degraded, disrupting the most common immune function and triggering chronic disease fighting capability activation which perpetuates irritation. While oxidative tension and inflammation are obvious players, studies offering antioxidants and anti-inflammatory agents show little impact on disease progression. Hence the necessity for novel biomarkers and treatment targets, said Dr. Ruth Caldwell, MCG vascular cell biologist and a report principal investigator. One of the many questions experts are asking is definitely whether IDO and arginine straight interact. They understand IDO and arginine are targets of interferon, a cytokine the physical body makes in response to invaders to help result in the immune response, stated Dr.